Manchester United manager Louis van Gaal was critical of the tackle that led to Luke Shaw suffering a double leg fracture against PSV.
The defender suffered the injury 15 minutes into the Champions League match when he was caught in the box by a sliding challenge from Hector Moreno.
The game was stopped for almost 10 minutes as Shaw was given oxygen and then taken off a stretcher.
He was subsequently taken to a hospital in Eindhoven while Moreno was not penalised for the challenge.
“When I say it was a penalty and red card I am a bad loser,” said Van Gaal after the 2-1 defeat. “Every word I say is always interpreted in the wrong way, but it was in the 16m [penalty area] and I think it was a very bad tackle with two legs.
“It is awful. He’s a boy who came to Manchester as an 18-year-old [in 2014], had a very difficult season, then second season he plays fantastic, and then this happens.
“When he was going into the dressing room he was with an oxygen mask and was crying.”
PSV coach Phillip Cocu defended Moreno, saying: “The intention was not to injure the opponent.”
Shaw is expected to travel back to Manchester with the rest of the squad on Wednesday before undergoing surgery.
Following the game, he wrote on Twitter: “Thank you everyone for your messages, words can’t describe how gutted I am, my road to recovery starts now, I will come back stronger.”
United players also posted messages of support for their team-mate on the social media site, with Ander Herrera writing: “Sad about the defeat but much sadder about Luke’s injury. Come back soon my friend.”
Phil Jones wrote: “Disappointing result tonight but thoughts are with Luke, stay strong mate!” United keeper David de Gea added: “Defeat hurts, but @LukeShaw23’s injury hurts even more. We hope you come back even stronger!”
Here are some of the other tweets directed to Shaw:
Chris Smalling (Manchester United): “My thoughts and prayers are [email protected] Hoping for a quick recovery and to be playing alongside him again as soon as possible!”
Nathaniel Clyne (Liverpool): “Gutted for you mate. Hope you have a speedy recovery”
Ross Barkley (Everton): “Thinking of you lad @LukeShaw23 hope you have a speedy recovery…”
James Ward-Prowse (Southampton): “Devastated to see that happen!! I wish you the speediest recovery @lukeshaw23 .. You will come back stronger mate”
Gareth Bale (Real Madrid): “speedy recovery mate, come back stronger!!”
Anthony Joshua (boxing): “My prayers and thoughts are with @LukeShaw23 stay strong through the recovery bro, come back stronger!”
Andy Murray (tennis): “Hope @Lukeshaw23 makes a full and speedy recovery…hate seeing young athletes getting injured like that”